The Lactanase Injection is an Enzymic modulator to reduce
lactic acid accumulation and delay muscle fatigue.
Contains: Dichloro-acetic acid 120 ug/mL Sodium gluconate 250 mg/mL Features
and Benefits
The LACTANASE is used to help reduce the incidence of Tying
Up by reducing the buildup of lactic acid in muscle cells.
Indications
LACTANASE contains dichloroacetic acid, which is an activator
of the enzyme pyruvate dehydrogenase. This enzyme plays a central role in the
process of lactic acid production during hard work.
Supplementation with dichloroacetic acid (DCA) results in activation of the
enzyme pyruvate dehydrogenase, leading to a reduction in the rate of lactic
acid production and accumulation in muscles. Elevated plasma lactate levels
result in a reduction in pH which contributes to muscle fatigue and decreased
muscle performance.
Supplementation with DCA has been shown to reduce lactic acid accumulation during
exercise, and produce a significant delay in muscle fatigue.
The pathogenesis of Exertional Rhabdomyolysis (“Tying Up”) in horses
is related to lactic acidosis during exercise, and associated low muscle pH.
Sodium bicarbonate and dimethylglycine (DMG), which may help to reduce lactic
acid accumulation during exercise, have been used to assist in the prevention
of Tying Up in horses. Similarly, DCA (LACTANASE) results in a reduction in
the rate of lactate accumulation, and a delay in the onset of muscle fatigue.
Dosage and Administration
Give 20 - 40 mL by intravenous injection (diluted in 1 Litre saline, or administer
via catheter) 1 - 2 times weekly.
WARNING: Take care to avoid leakage from the vein. LACTANASE
is highly irritant if given outside the vein. Avoid accidental contact with
mucous membranes or eyes (avoid accidental spillage or spray).
Presentation
100 mL sterile glass multidose vial.
Storage
Store below 25o C (air conditioning). Protect from light.
See Also: Tridenosen Injection, Tie Up Injection, L-Carnitine Injection
For: Race Horses, Dog, Greyhounds, Camels
Trainers Tips:
Best used when given 20-40mL IV (diluted in 1 Litre saline, or administer via
catheter) 24hrs prior to event
