Toltrazuril is
the result of research efforts. Thanks to its characteristics, it represents a
new standard in coccidiosis control in Race Horses, Camels, Pigeons, Greyhounds
& Alpacas.
Toltrazuril
belongs to the chemical group of “symmetric triazinons” and is not chemically
related to any other anticoccidial drug currently used in veterinary medicine.
This is a 5% solution.
Due to its
particular mode of action, which affects all intracellular structures of
Coccidia, Toltrazuril demonstrates very high efficacy, as shown by the
following benefits:
Coccidiosis: Coccidiosis
is an infection of intestinal epithelium caused by protozoan parasite of family
Eimeriidae.
All livestock
species, as well as wild animals, can be infected. Coccidiosis is especially
prevalent when birds or mammals are grouped together. Coccidia oocysts are
highly resistant to environment conditions, and disinfectants, making
coccidiosis control difficult.
Coccidiosis is
characterised by an invasion of the intestinal wall by the Coccidia parasite.
The parasite then goes through several stages of growth and multiplication,
during which damage occurs to the mucosal and submucosal tissues of the
intestine.
Depending on
the Coccidia strain involved and the animal species affected, the disease
complexes can range from subclinical infections to infections that include
severe intestinal problems with severe lesions in the gastrointestinal tract,
to diarrhoea that can result in high mortality and/or a negative impact on the
factors of production.
For the
aforementioned reasons, several research institutes have put a great deal of
effort into developing different options for controlling coccidiosis. Baycox
(toltrazuril), which represents one of the most efficient ways to control and
prevent coccidiosis in various animal species.
Toltrazuril
demonstrates powerful anticoccidial activity against different stages in the
life cycles of the various Eimeria spp. of birds and mammals. It has produced
excellent results in therapeutic and metaphylactic programs for a range of
animal species.
Toltrazuril -
Mode of Action -Toltrazuril damages all intracellular development stages
of Eimeria (= Coccidia). Toltrazuril affects schizonts, micro- and macrogametes,
but not the tissue cells of the host animals, as was shown in light and
electron microscopic studies.
These findings
suggest that toltrazuril interferes with the division of the nucleus and with
the activity of the mitochondria, which is responsible for the respiratory
metabolism of Coccidia.
In the
magrometes, toltrazuril damages the so-called wall-forming bodies. In all
intracellular developmental stages, severe vacuolisation occurs due to
inflation of the endoplasmatic reticulum.
Toltrazuril
thus has a coccidiocidal mode of action.
The special
mode of action results in the following advantages:
* Toltrazuril
acts on all intracellular developmental stages,
* Toltrazuril
does not interfere with the development of immunity
*follow-up
treatment usually is not necessary
*even an
advanced infection (after 3 – 5 days; gametogony) can still be treated
successfully,
*the efficacy
of Toltrazuril is independent of the severity of the infection.
